Regenerative Medicine Utrecht


PhD student

CF (“cystic fibrosis”) is a genetic disease that affects more than 70,000 individuals worldwide due to approximately 2,000 different mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Two CFTR protein-restoring therapies have recently been introduced on the market, but these are only beneficial for a limited number of CF patients. In this project, the candidate will use patient-specific stem cell culture technology (e.g. intestinal organoids) to (i) explore novel therapeutic approaches to enable treatments of patients that are currently devoid of any CFTR-targeted therapies, and (ii) to identify mechanisms associated with therapeutic variability of current CFTR modulators. Together, this research aims to identify new diagnostic applications and drug targets to improve personalized treatment of CF patients. more information