Regenerative Medicine Utrecht

Stem Cell & Organoid Biology

We focus on using stem cells for transplantation therapies, organoids for screening and therapeutic use, and also on approaches that stimulate our own stem cells to repair our bodies.

Unraveling control mechanisms of cell proliferation

Understanding how cells function may lead to new therapies. Read about Alain de Bruin’s research.     This cycle of duplication and division, known as the cell cycle, is regulated by countless regulatory mechanisms that can speed up or slow down cell proliferation. These control mechanism are often misregulated in geriatric patients. When people get…

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Liver regeneration

We’re finding new ways to overcome the shortage of organ donors. Read about Bart Spee’s research.   The shortage of donors for liver transplants is a growing problem, in Europe alone, 22% of patients on the waiting list for a liver transplant die. Alternatives are needed to treat the increasing number of patients with liver…

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Zooming in on Wnt proteins

Many human diseases are linked to Wnt signaling Read about Madelon Maurice’s research.     We aim to understand how cells communicate in the human body. Cells commonly send and deliver their messages via secreted proteins. The underlying mechanisms by which cells interpret these messages fascinate us. We study one particular group of proteins, called…

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Improving hematopoietic stem cell transplant

We develop novel stem cell-based therapies for blood disorders.   Read about Jaap Jan Boelens’research.     Our research focuses on safer and more effective HSCT, and we’re also interested in HSCT in rare non-hematopoietic diseases, for example, lysosomal storage disease and epidermolysis bullosae (EB). In close collaboration with Stefan Nierkens, PhD of the Immunology…

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Understanding neuronal connections in ALS and epilepsy

We’re uncovering new therapeutic interventions for neuronal degeneration. Read about Jeroen Pasterkamp’s research. The focus of my lab is directed towards understanding the signaling events and molecular mechanisms involved in the formation of neuronal connections during development; and also the molecular mechanisms underlying changes in or loss of neuronal connectivity during neurological disease. In particular,…

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