Regenerative Medicine Utrecht

Internships for Master students

Master internship: controlled immune stimulation

Department of Orthopedics, University Medical Center Utrecht

Project description
Our department is looking for a student who will contribute to the development of immune-modulating biomaterials for bone repair. This position is set in a multidisciplinary team with biologists, biomaterials scientists, and clinicians, hence this project gives the candidate the unique opportunity to work in a very dynamic environment.

The clinical observation that certain infectious conditions lead to huge amounts of new bone formation, initiated a research line where bacterial components are being
explored for their bone-inductive properties. Furthermore, coating methods are being optimized to improve their immunogenic and bone-inductive properties. In a
final stage, the subset of novel and promising deliverables will be tested in preclinical bone healing models. The student will become experienced in techniques
such as cell culture, stem cell isolation and differentiation, biomaterial optimization, different imaging and histological techniques, and in vivo experiments (when

Your work is performed with close to 50 other researchers in the Orthopedics lab, which is part of the Regenerative Medicine Center Utrecht (RMCU). The RMCU
brings together fundamental, translational and clinical scientists to develop regenerative medicine therapies for personalized care (see

You are a highly motivated individual, with a degree in a bio (medical) track. You are available for an internship of at least six months. You have affinity with
immunology and/or materials science-related topics, and have prior hands-on experience with cell culture and cellular assays. Ideally, you are interested in helping
with animal experiments and/or hold an article 9 certificate.

Interested applicants should send their CV and motivation letter to dr. M. Croes (, + 31 0 619422313). Please also include your preferred
internship period and specific research interests.