RM seminar dr. Peter L.J. de Keizer
“Targeted Apoptosis of Senescent Cells against Aging and Cancer”
Senescent cells are a cause for certain aspects of aging and can confer resistance of cancer cells to therapy. As we showed recently (Baar et al, 2017, Cell), the transcription factor FOXO4 is pivotal in the maintenance of the viability of senescent cells and targeting the FOXO4-p53 pathway with specific peptides can result in health benefits in aging mice. In addition, we found that certain therapy-surviving cancer cells upregulate FOXO4 signaling as well and these peptides are highly potent in selectively eliminating those. Our goal is to improve these compounds to eventually be ready for human translation.