RM Seminar Prof. dr. Daniel J Kelly
Daniel Kelly is Professor of Tissue Engineering in Trinity College Dublin and Director of the Trinity Centre for Bioengineering (TCBE). He is also one of the founding Principal Investigators of the Advanced Materials and Bioengineering Research (AMBER) centre based in Trinity College Dublin. Prof Kelly received a Science Foundation Ireland President of Ireland Young Researcher Award, a Fulbright Visiting Scholar grant (at the Department of Biomedical Engineering in Columbia University, New York) and three European Research Council awards (Starter grant 2010; Consolidator grant 2015; Proof of Concept grant 2017). His research focuses on developing novel tissue engineering and 3D bioprinting strategies to regenerate damaged and diseased musculoskeletal tissues.
Dr. Kelly’s lab is pioneering the use of adult stem cells isolated from synovial joints such as the knee, combined with bioreactors to mechanically stimulate these cells, to tissue engineer functional cartilage grafts. They have demonstrated that it is possible to engineer zonally organised tissues such as articular cartilage by recapitulating the gradients in regulatory signals that during development and skeletal maturation are believed to drive spatial changes in stem cell differentiation and tissue organization. They are also developing single stage therapies for articular cartilage regeneration that combine biomimetic scaffolds with freshly isolated stromal cells sourced from patients in-clinic. Bone, joint and limb regeneration: Dr. Kelly’s lab has also demonstrated how complex tissues, such as the bone-cartilage interface, can be regenerated by designing tissue engineering strategies that recapitulate aspects of the normal long bone developmental process. They have also been able to scale-up this process to tissue engineer entire new bones. They are currently extending this strategy to tissue engineer whole joints using adult stem cells and 3D bioprinting. Stem cell mechanobiology: Dr. Kelly’s lab is investigating how extrinsic mechanical cues can regulate stem cell fate. His lab has also identified novel roles for both mechanical signals and oxygen in regulating chondrogenesis and hypertrophy of MSCs.