Regenerative Medicine Utrecht

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Women in Science: Marianna Tryfonidou

Utrecht University’s women professors, like Johanna Westerdijk, the university’s first female professor, inspire future generations.

“We develop treatments that have an avalanche effect.”

Marianna Tryfonidou, DVM, PhD
Professor in Regenerative Orthopedics
Faculty of Veterinary Medicine, Utrecht University

Research: Regeneration of intervertebral discs (cartilage regeneration).

Neck and back pain are usually associated with degeneration of intervertebral discs (the squishy parts between your vertebrae). Patients usually undergo pain management and late stage patients need surgery, where two vertebrae are fused together, which has long recovery and is not a cure for the disease.

Marianna focuses on stem cell-based regeneration of intervertebral discs using the canine model. Dogs develop spontaneous IVD degeneration which closely mimics the degenerative process in humans. Her pre-clinical model helps translate potential therapies to the human clinic (she works closely with the Orthopaedics Department, UMC Utrecht), while treating animal patients at the veterinary clinic.

Brief bio of Marianna
Marianna received her Veterinary Medicine degree from Aristoteles University in Greece and her PhD, cum laude, from Utrecht University on the role of vitamin D3 metabolism in skeletal development in growing dogs. Following her PhD, she specialized in surgery at Utrecht University. Since 2018, Marianna is a Professor in the Faculty of Veterinary Medicine, focusing on regenerative orthopaedics, participates at several Dutch and EU consortia grants and contributes as a lecturer for various educational activities.

Key words: regenerative medicine, cartilage regeneration, IVD degeneration, bioengineering, canine, veterinary medicine, orthopaedics, musculoskeletal

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