Cardiovascular Tissue Regeneration
Cilium and kidney disease
My inspiration grows from understanding how a gene works.
Read about the reserach in Rachel Giles’group.
Cilia are hair-like organelles present on almost every cell type in our bodies. They detect changes in the microenvironment and help our cells respond, for example, initiating cell replacement after injury.
My lab focuses on understanding how the cilium regulates renal epithelial regulation. Our questions focus on studying ciliary regulation of the cell cycle and cell signaling using in vitro renal cell culture and proteomics, ex vivo whole kidney culture, and in vivo zebrafish models of renal cell carcinoma and renal ciliopathies. We apply our understanding of kidney cell regulation to renal regeneration. We have invested in an integrated systems biology approach to understand the cilium in proliferative states such as tissue regeneration and nephronophthisis/polycystic kidney diseases. Finally, the generation of iPSC cells from our pediatric patients aids renal disease modeling and drug screens.
Click here for Rachel’s profile.