My lab focuses on understanding how the cilium regulates renal epithelial regulation. Our questions focus on studying ciliary regulation of the cell cycle and cell signaling using in vitro renal cell culture and proteomics, ex vivo whole kidney culture, and in vivo zebrafish models of renal cell carcinoma and renal ciliopathies. We apply our understanding of kidney cell regulation to renal regeneration. We have invested in an integrated systems biology approach to understand the cilium in proliferative states such as tissue regeneration and nephronophthisis/polycystic kidney diseases. Finally, the generation of iPSC cells from our pediatric patients aids renal disease modeling and drug screens.
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