microRNAs and heart disease
What signaling mechanisms are important in heart disease?
Eva van Rooij
A major challenge in the field of cardiovascular biology is to decipher the relevance of different signaling mechanisms during disease. Our lab is interested in molecular mechanisms underlying cardiovascular disease conditions by studying the complex interplay between gene expression and microRNAs.
Groundbreaking discoveries in the field of microRNA biology by our group and others have shown that these small, non-coding RNAs have a very potent and relevant influence during disease. Using molecular in vitro and in vivo gain and loss-of-function studies, applying both genetics and oligonucleotide-based approaches, we aim to further delineate the morphological and functional relevance of different signaling molecules.
Our longterm goal is to increase our understanding in how changes in gene expression and microRNA function contribute to disease to allow for the development of novel cardiovascular therapeutics.
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