Working side-by-side with clinicians is essential.
My research focuses on improving regeneration of cartilaginous tissues, such as the intervertebral discs and articular cartilage (which covers bone ends in a joint).
We study inflammatory pathways and epigenetic changes involved in the regeneration and degeneration of these tissues. Our strategies involve the development of biomaterial-based local controlled release systems, and non-viral genetic modulation (in particular by RNAi) to enhance a regenerative phenotype in native and retransplantedmy research, the embedding in a group containing clinicians keen on bringing new treatments to the patient has been very stimulating. In addition, the BioBank facility is important in providing human material indispensable for our research. The research environment in the UMC Utrecht is pleasant and most groups are open to collaboration or sharing of equipment.
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